Polycystic Kidney Disease - Methods in Signal Transduction Series

This volume focuses on the investigatory methods applied to autosomal dominant polycystic kidney disease (ADPKD), one of the most common human genetic diseases. ADPKD is caused by mutations in PKD1 and TRPP2, two integral membrane proteins that function as receptor/ion channels in primary cilia of tubular epithelial cells. Thus, ADPKD belongs to ciliopathies, a group of disorders caused by abnormal cilia formation or function. This proposed book will cover the state-of-the-art methods ranging from molecular biology, biochemistry, electrophysiology, to tools in model animal studies.Key Features Explores the role of cilia in polycystic kidney disease Focuses on myriad state-of-the-art methods and techniques Reviews specific mutations integral to this autosomal genetic disease Includes discussions of model systems

ISBN:	9781138603899
Publisher:	CRC Press
Imprint:	CRC Press
Published date:	14 Nov 2019
DEWEY:	616.61042
DEWEY edition:	23
Language:	English
Number of pages:	346
Weight:	724g
Height:	162mm
Width:	240mm
Spine width:	26mm

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